Exact(11)
The luckless fools flick the switches I disconnected earlier, while Conway calmly travels overhead like a ghost.
Those 9,000 switches: I went to KAS with Master Sound in 1984 when it rented space there, and I was in the partnership that bought out Master Sound in '87.
However, unlike MnmE, it does not dimerize in the transition state, suggesting alternative ways to stabilize switches I and II.
Switches I and II are at the core of GTPase function, undergoing conformational changes between GTP and GDP binding states [ 23].
Thus the functional divergence in aSelBL in switches I and II may have involved modification or refinement of tRNA-binding capabilities.
Regions surrounding the G2-G3 domain, i.e. β1-β2 and β2-β3 loops, were predicted to be Switches I and II, respectively.
Similar(49)
That play will be exactly the switch I need now.
Grey shaded areas indicate Switch I and II effector domains.
It has a converter domain, and a P-loop, switch I and switch II near the active site.
Helix α7 is close to the P-loop as well as to switch I in Rap1B.
M+ binding is mediated by Asp in the P loop and Gly in Switch I.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com