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The drug was discontinued, and treatment was switched to maintenance risperidone 1 mg.
After 48 hours, cells were switched to maintenance DMEM medium containing 10% FBS and 830-nM insulin for the remaining duration of differentiation.
At 2 weeks after the first passage, the cells were switched to maintenance medium containing N2 supplement (1%; Invitrogen) and 20 ng/ml EGF.
Once disease control has been achieved, treatment can be switched to maintenance therapy with a better tolerated drug.
If splenectomy, romiplostim, and rituximab are all ineffective or relapse occurs, then the patient is switched to maintenance therapy using corticosteroids.
However, these patients would have an improved outcome if they switched to maintenance treatment with less potent and toxic drugs [ 2].
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However, the rate of AEs including diarrhea, food-hand reaction, and neuropathy was significantly higher in patients continuing chemotherapy than in patients switching to maintenance treatment [ 18].
Several phase III clinical trials suggested that if the patient obtains a maximum response after 3 6 months of first-line treatment, he/she can switch to maintenance therapy [ 5, 6, 15].
39 Maintenance treatment follows directly on from the induction phase and is normally started after the 2-week treatment phase provided there has been a good clinical response, although some clinicians prefer to repeat the CSF examination and only switch to maintenance therapy once CSF culture is cryptococcus negative.
Dietary restriction seems to set off an ancient strategy written into all animal genomes, that when food is scarce resources should be switched to tissue maintenance from breeding.
Many other species have much the same reflex, and some biologists believe this is an ancient survival strategy, in which during times of famine the body's reserves are switched to tissue maintenance, with the hope of riding out the bad times and breeding later.
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