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This has been in part because of the strategy of the early delivery of a non cross-resistant agenon cross-resistanthemotheragentnow termed switch mafternance theraplatinum
Several phase III trials with both chemotherapeutic and targeted agents have demonstrated either PFS prolongation (continuation maintenance) or both PFS and OS benefit (switch maintenance).
Phase III trials have demonstrated an improvement in overall survival with switch maintenance therapy with pemetrexed compared with placebo in patients with nonsquamous histology and erlotinib compared with placebo.
Two different approaches have been evaluated; the so-called continuation maintenance when the maintenance agent was part of initial therapy and is continued in the absence of disease progression ("maintained") or switch maintenance when a third agent is initiated after a defined number of cycles chemotherapy in the absence of disease progression.
Pemetrexed switch maintenance treatment has been widely recommended for patients with advanced NSCLC.
Switch maintenance chemotherapy can be recognised as an early second-line chemotherapy.
Similar(41)
We prospectively evaluated the safety and effectiveness of switching maintenance dialysis patients from sevelamer hydrochloride to BXL.
EnerNOC's software platform can notify manufacturers when they should switch into maintenance mode for a few hours, or advise office managers to scale back air conditioning use.
Prof Les Ebdon, director of Fair Access to Higher Education, said it was impossible to know how the switch from maintenance grants to loans would affect aspiration to study but he would be watching closely for any impact.
Jack Britton, research economist at the IFS, said: "While the small increase in support for living costs available to students from lower-income families will be welcomed by many, the switch from maintenance grants to loans will result in substantially higher debt for the poorest students.
We analyse current approaches to the design of attention aware systems along three major features: detection of user's current attentional state, detection and evaluation of possible alternative attentional states, strategies for focus switch or maintenance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com