STAT6 is activated in response to IL-4 and functions as the molecular switch for initiation of the Th2 cell differentiation program.
Signaling pathways following apoptosis-inducing stimuli either arrest the cell cycle following damage signals to allow time for repair or switch to initiation of apoptosis after apoptogenic agents.
Finally, another difficult situation is when the originally assigned (intended) treatment switches before initiation.
Treatment persistence was defined as a patient remaining on the study drug during the follow-up period, without discontinuation or switching after initiation.
Intriguingly, TBP, which in oocytes is undetectable at the protein level, can functionally replace TBP2 when ectopically expressed in oocytes, showing that switching of initiation factors can be driven by changes in their expression.
TBP2 promotes RNAP-II transcription in oocytes, but ectopically expressed TBP can do the same, showing that switching of initiation factors can be driven by expression levels in this system.
Newly made proteins destined to be inserted into membranes trigger an RNA switch that promotes initiation of this process.
Although visual processing appears independent of the P1 neuronal pathway, these data support the view that, by integrating multimodal sensory signals, P1 interneurons mediate the decision to initiate courtship, effectively acting as a switch for courtship initiation [ 26,53,54].
The results clearly show that SCARB2 acts as a pH-dependent molecular switch for the initiation of uncoating.
Changes in excitability are explained by a switch in spike initiation dynamics.
These data clearly demonstrate criticality and support our attribution of it to a switch in spike initiation dynamics.
