Sentence examples for switch in phenotype from inspiring English sources

Another significant recent insight has been that the EMT-like switch in phenotype is associated with a concomitant change in the expression of multiple tumor antigens, ultimately allowing cells to evade T-cell killing.

Finally the ability to convert A-549 human NSCLC cells to metastasising cells by forced MYC expression now enables us to study the sequence of events required for this switch in phenotype.

It has been appreciated for some time that primary RPE cells, like many cells, undergo a permanent switch in phenotype with repeated passage [ 30].

GDF6 is nearly exclusive to P5 RPE cells and as such it is a candidate ligand for mediating the irreversible switch in phenotype following sustained wound stimulus.

It has been reported that this indicates a poor prognosis (Wulfing et al, 2006); it is not clear whether these cells represent a switch in phenotype or a subgroup of pre-existing cells within the primary tumour.

The generation of an in vitro model for transdifferentiation (discussed below) has provided some of the molecular details for the switch in phenotype from a pancreatic to a hepatic cell type.

The switch in phenotypes is mediated by the agr QS system, the key regulator of gene expression in S. aureus and a vital determinant of species evolutionary diversification (Novick & Geisinger, 2008; Wright et al, 2005b).

Our data demonstrate a lipogenic-to-myogenic switch in fibroblastic phenotype during fibrosis formation.

Here we show that the gastric environment can contribute to a switch in Lewis phenotype in the two experimental mouse models.

Here, we demonstrate that femoral artery occlusion induces a switch in macrophage phenotype through angiopoietin-1 (ANG1 -mediated Phd2 repression.

As a result, there is a switch in the phenotype of the sensory neurons and their pain signaling mechanisms.