Sentence examples for switch factors from inspiring English sources

IL-13 and IL-4 have both been shown to be switch factors for IgE production (Punnonen et al., 1993 and Pène et al., 1988 respectively).

Moreover, T cell-derived cytokines, such as IL-10, have been reported to be involved in the regulation of switch factors for IgG3 [ 55].

These factors have been implicated in EMT by a study that has shown that the master switch factors SNAI1 and SNAI2 recruit the Sin3a/HDAC1/HDAC2 complex to silence CDH1 in EMT [ 66].

Many more of such switch factors will undoubtedly be found in the future which will help to understand how exactly the various biochemical pathways interact with one another and how they could become amenable to subversion.

It is not known what factors determine whether the activation of mTOR will favor anabolism or catabolism; however, given the importance of its final outcome, investigating the switch factors will be an interesting subject for future studies.

Noting that induction of effector T-cells (Teffs) and regulatory T-cells (Tregs) occurs during infection, inflammation, and autoimmunity, von Herrath addressed the understanding of "switch factors" such as specific cytokines that will favor Tregs rather than Teff "to recruit your own immune system to do the job".

The transcription factor PR domain containing 16 (PRDM16) is a critical switch factor in determining the commitment of mouse Myf5+ precursors to brown adipocytes versus myogenic cells (Jimenez-Preitner et al., 2011; Kajimura et al., 2009).

In addition to being a class switch factor, IL-4 enhances B cell survival and proliferation [65], [66].

Autocrine IFN-γ may be particularly important as a switch factor for IgG3 in response to T-independent antigens [ 63].

Moreover, S1PR1 is a switch factor that inhibits the development of anti-inflammatory regulatory T cells but drives differentiation of proinflammatory T helper type 1 cells (Th1) [ 12].

We hypothesize that 501mel cells secrete factors that induce an elongated morphology in WM266-4 cells thereby constraining them to adopt a protease-driven leader role in invasion; however, this soluble "switch factor" can be cleaved by proteases secreted by WM266-4 cells, allowing them to use "rounded" invasion when the "switch factor" is sufficiently neutralized.