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Although there are many diverse primary signals that initiate the cascade (e.g. X A ratio, M-factors, W/Y chromosomes; see [ 1]), dsx appears to be conserved as the major switch at the base of the cascade [ 8, 9].
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Changes in protein structure between the transcribing complex and free enzyme include closure of a clamp over the DNA and RNA and ordering of a series of "switches" at the base of the clamp to create a binding site complementary to the DNA-RNA hybrid.
It doesn't add too much extra girth to the svelte device and comes with an on/off switch (located at the base for the reserve battery.
Furthermore, these key glutamate residues lining the QacR multidrug-binding pocket may collectively provide a formal negatively charged pathway geared to drive cationic ligands, as much as their structures will sterically allow, toward switch residues T89-T93 athehe base of the pocket.
Realistic-looking, veined and arched, a switch at its base.
Consistent with the evidence that there was little sequence variability in the chCaRE sequence at positions 3, 6, 7, and 8 (Figure 5a) switching the base at any of these positions essentially eliminated the ability of the altered oligo to compete the binding of CaRF to the camCaRE (Figure 5c).
This introduced the notion that the situation might be more complex than alternative switching of two steadfast antagonistic motors at the base of the Tff, and that hetero-hexamers or higher order complex motors might exist.
As the P-loop pulls away from the switch loops, a bifurcated hydrogen bond breaks up between T92 at the base of the P-loop and S202/D231 in switches I and II.
At the base.
The NATO spokeswoman at the base, Maj.
Remove the seed pod at the base.
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