Assuming that, on average, each Dronpa molecule switches approximately three to five times (31), the number of labeled CENP-A molecules is approximately 25 to 40.
The outdoor temperature for the mode switch was approximately 8.3 °C.
These switch points approximately coincide with the global minimum and maximum values of the cumulative GC-skew (fig. 1 A, black arrows).
Subjects were required to keep their hand on a switch placed approximately 40 cm from the body, at midline (Fig. 2).
Our modeling indicated that this assumption would hold as long as the promoter strengths of the two transcription factors in the toggle switch were approximately equal.
To comply with the requests of the reviewers, we have expanded the explanation of the model ("We ranked the cells according to the ratio in the toggle switch were approximately equal").
For comparison we also sequenced matching fractions from before (40 hours) and after (93 hours) the switch, returning approximately 16 million sequenced small RNAs (Additional file 1: Figure S5C).
We observe that after learning, RL Scheme tends to reduce the number of channel switches to 19.0, wherein GD-20 Scheme keeps the channel switches to approximately 29.0, GD-1 Scheme keeps the channel switches to approximately 67.4, and RA Scheme keeps the channel switches to approximately 66.8.
Otherwise, the switching efficiency could be 80% or better, and the power dissipated by the ensemble of gates during switching was approximately 0.1 nW cm−2, which is orders of magnitude less than the power dissipated during switching of an equivalent array of transistors.
With regard to synchronization, switching delay effects are expected to be negligible as the selected devices perform switching in approximately 1 time-domain sample for the LTE system where, given a maximum number of subcarriers of 2048 with 15 kHz separation, the sampling time is T s = 1 / (15 · 103 × 2048 s ≈ 32.5 ns.
