The site percolation threshold (based on the release properties) ranged between 10 and 20% v/v of the excipient, the site-bond percolation threshold (estimated from the mechanical properties) between 29.5 and 34% v/v of the excipient and the swelling percolation threshold between 34.3 and 46.9% v/v of the excipient.
It was found that a 10% gas-swelling threshold is appropriate for a wide range of gas bubble sizes.
In addition to these improvements, a probabilistic approach is taken to verify the fission gas-swelling threshold at which interconnected porosity begins.
Since the brain is confined in an inextensible, rigid structure, cell volume regulation is crucial as any excessive increase in cell volume resulting in brain swelling over a threshold of 10%% equates with severely elevated intracranial pressure, placing the patient at risk of serious brain injury and, ultimately, brain herniation [50, 51].
Their explanation as to how this is achieved is that swelling increases the threshold at which ROS induce the permeability transition.
Percentage inhibition for individual treatment groups are calculated by normalizing Area Under the Curve (AUC) for paw swelling and withdrawal threshold by fitting SCW vehicle groups to 100% and non-arthritic controls to 0%.
Since the brain is confined in an inextensible, rigid structure, cell volume regulation is crucial as any excessive increase in cell volume resulting in brain swelling over a threshold of 10%% equates with severely elevated intracranial pressure, placing the patient at risk of serious brain injury and, ultimately, brain herniation [ 50, 51].
Microfibrillated cellulose (MFC) films containing the water soluble and pharmaceutically approved polymer hydroxypropyl methylcellulose (HPMC) exhibited an unexpected decrease in permeability and excellent one-dimensional swelling properties above a threshold in HPMC content.
Because pregnancy is known to be a risk factor for venous thromboembolism and pregnant women often experience symptoms compatible with deep vein thrombosis (pain, tenderness, and swelling of the legs), the threshold for clinical suspicion and the accuracy of clinical examination are reduced.
A new model is presented, allowing for mass transfer with chemical reaction whilst assuming power-law kinetics for the velocity of the swelling front: where c*a is the threshold concentration for swelling, ca,r=r0 the concentration of penetrant A at the position r0 of the swelling front and K a constant independent of the penetrant concentration.
