This paper analyzes a dynamic and general scenario, in which: (i) workers can leave the network at any time; (ii) each job is executed multiple times, either to obtain better statistical accuracy or to perform parameter sweep analysis; and, (iii) input data is replicated and distributed to multiple data caches on-the-fly.
In addition, the definition of the mathematical model benefited from a preliminary bioinformatic process based on three-dimensional protein structure modeling, to confirm the actual spatio-temporal cascade of PRR interactions, and on a successive computational phase based on parameter sweep analysis and sensitivity analysis, to test the reliability of the chosen model parameterization.
We present the biological results achieved with a massive exploration of perturbed conditions of the BCC, carried out with one-dimensional and bi-dimensional parameter sweep analysis, and show that GPU-accelerated parallel simulations of this model can increase the computational performances up to a 181× speedup compared to the corresponding sequential simulations.
This approach combining selective sweep analysis and QTL mapping allowed a reduction in the size of the four QTL regions from, on average, 12 Mb to 100 kb, with some of these regions now containing one gene, therefore standing as strong causal positional candidate.
DN performed the experiments, analysis and lab work, JB and MJ assisted in HRM-analysis, CR performed the sweep analysis, DW performed the F8-breeding and genotyping, LA developed the intercross analysis, and PJ, together with DN, planned and conceptualised the experiment, and wrote the paper.
An integrated method using Campbell diagram, modal energy and speed sweep analysis is presented to identify the resonances of the electromechanical system.
Gel stability was demonstrated in frequency sweep analysis, which verified that storage and loss moduli were independent of applied angular frequency.
In particular, we exploit coagSODA to carry out one-dimensional and bi-dimensional parameter sweep analysis of the BCC, to the purpose of investigating the prolongation and the reduction of the clotting time in response to perturbed values of some reaction constants and of the initial concentration of some molecular species, chosen according to their meaning within the whole pathway.
The system of ordinary differential equations (ODEs), needed to carry out the simulations and the parameter sweep analysis presented in Section 3, was derived from the reactions given in Table 1 according to the mass-action law, with the exception of 14 reactions belonging to the set S ɛ = { r19, r21, r23, r29, r31, r35, r46, r49, r52, r62, r70, r73, r76, r82}.
First, our sweep analysis was performed using population-specific data, and thus, any selective signal will be unique to a single population, whereas the Green et al. scan was based upon detecting a joint signal from all five populations considered.
Apart from the above mentioned QTL and association analysis methods, selective sweep analysis is another approach that can be used to detect loci of potential agronomic importance.
