Sentence examples for sustains the activation of from inspiring English sources

G388R sustains the activation of FGFR4 [ 125], and human cancers characterized by this SNP were reported to be highly aggressive and metastatic in nature [ 124, 126– 126].

In this, caveolin-1 sustains the activation of the mTOR pathway leading to HIF-mediated angiogenesis via upstream inhibition of a protein phosphatase that in turn causes loss of repression of both AKT and ERK1/2 (see schematic Figure 4).

We propose that continuous transcription of mitotic regulators is required to sustain the activation of the spindle assembly checkpoint.

This confirms the kinase-substrate relationship between these proteins, and highlights the essential contribute of AMPK in sustaining the activation of this pathway.

Our supporting evidence is that complement C1q and C6 sustain the activation of tumor suppressor WOX1, which is needed for blocking cancer cell proliferation.

Thus, the critical impact of vinculin's intramolecular regulation on the cellular control of adhesion sites appears to be a consequence of its capacity to sustain the activation of talin and subsequently of integrin [20].

This model indicated that GDIs sustain the activation of Rho GTPase by interacting with GAPs.

Such disease pathways include the process of lymphoid organogenesis as well as sustaining the activation of tissue resident fibroblasts.

We found that SOCS1 and SOCS3 suppress cytokine-induced apoptosis by sustaining the activation of the PI3K/AKT pathway in keratinocytes.

Firstly, we demonstrated that SOCS1 and SOCS3 molecules, both abundantly expressed in psoriatic epidermis, suppress the IFN- γ/TNF- α-induced apoptosis in human keratinocytes by specifically sustaining the activation of the anti-apoptotic PI3K/AKT pathway.

Thus, after the initial Akt/Foxo activation, the up-regulation of the NF-κB pathway from 5 to 14 days is suggested to sustain the activation of Murf1 and protein degradation.