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We conclude that Src activation sustains cell proliferation by potentiating ERK activation and Cyclin D1 upregulation.
Filadi, R. et al. TOM70 sustains cell bioenergetics by promoting IP3R3-mediated ER to mitochondria Ca2+ transfer.
Both EVL and myosin II-dependent cell stiffening potentiates ERK activity, sustains cell proliferation, as well as enhance Src activation.
Altogether these observations demonstrate that EVL is required for Src-dependent ERK activation, which upregulates Cyclin D1 and sustains cell proliferation.
Accordingly, we show that EVL and Myosin II activity potentiates ERK activation, which, in turn, upregulates Cyclin D1 and sustains cell proliferation.
Dexamethasone-induced PLT2 expression in ABP1 inactivated roots did not reactivate cell division (Figure 5), coherent with previous data supporting that PLT overexpression sustains cell division only in cells that still have the capacity to divide [22].
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In addition to EVL, other ABPs might be involved downstream of Src to sustain cell proliferation.
p.1171 left column top paragraph:"Capacity of the vacuolar zinc store to sustain cell growth.
Gomes, L. C., Di, B. G. & Scorrano, L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.
Gomes, L. C., Di Benedetto, G. & Scorrano, L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.
Once printed, an inlet and outlet own opposite ends are perfused with fluids, nutrients, and cell growth factors, which control stem cell differentiation and sustain cell functions.
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