Sentence examples for sustaining the malignant from inspiring English sources
However, despite the potential importance of epigenetic modifications in human cancer, it has been difficult to determine when, where and how epigenetic disruptions occur, and if they have important functional roles in sustaining the malignant state.
Recently, it was shown that glioma-associated stem cells produce substantial amounts of exosomes that exhibit glioma stem cell features and that are capable of sustaining the malignant properties of both glioma cells and glioma stem cells, mainly through the release of exosomes [ 105].
In Notch-dependent T-ALL, pre-TCR signaling was required to condition mice for the Notch-dependent transformation but it was not required to sustain the malignant growth of the T-ALL [ 98].
24, 25 Surrounding tumor stromal cells, while not having the marked genetic instability of tumors, have been shown to undergo genetic alteration in response to the presence of a tumor; these may further sustain the malignant phenotype.
The fact that a genetic alteration with a prognostic significance also plays a causative role in sustaining the mammary malignant phenotype made HER2 an attractive target for therapeutic inhibition.
"The challenge is sustaining the victory.
Our central challenge is sustaining the momentum.
APRIL could sustain the survival of malignant cells directly through HS proteoglycans that can deliver signals through their intracellular tails upon binding to ligands[ 66, 67].
GSK-3 sustains the growth of malignant blood cells, like chronic lymphocytic leukemia (CLL) [ 34] and acute myeloid leukemia cells (AML) [ 49].
It remains largely unknown whether "protective autophagy" might also sustain the survival of premalignant or malignant progenitor cells with the intraductal environment of the DCIS lesion.
