Sentence examples for sustaining the activation of from inspiring English sources

This confirms the kinase-substrate relationship between these proteins, and highlights the essential contribute of AMPK in sustaining the activation of this pathway.

Such disease pathways include the process of lymphoid organogenesis as well as sustaining the activation of tissue resident fibroblasts.

We found that SOCS1 and SOCS3 suppress cytokine-induced apoptosis by sustaining the activation of the PI3K/AKT pathway in keratinocytes.

Firstly, we demonstrated that SOCS1 and SOCS3 molecules, both abundantly expressed in psoriatic epidermis, suppress the IFN- γ/TNF- α-induced apoptosis in human keratinocytes by specifically sustaining the activation of the anti-apoptotic PI3K/AKT pathway.

The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN -γ and IFN -γ[ 21, 22].

In particular, SOCS1 can repress apoptosis induced by TNF- α by sustaining the activation of p38 MAP kinase signaling in murine fibroblasts or by inhibiting JAK activation in Jurkat T-cell line, whereas SOCS3 has been reported to inhibit TNF- α-induced apoptosis in pancreatic beta cells by impairing the activation of ERK1/2, p38 and JNK pathways.

In addition, high levels of cellular ROS can sustain the activation of ERK, which is reportedly observed in senescent cells27.

We propose that continuous transcription of mitotic regulators is required to sustain the activation of the spindle assembly checkpoint.

Our supporting evidence is that complement C1q and C6 sustain the activation of tumor suppressor WOX1, which is needed for blocking cancer cell proliferation.

Thus, the critical impact of vinculin's intramolecular regulation on the cellular control of adhesion sites appears to be a consequence of its capacity to sustain the activation of talin and subsequently of integrin [20].

This model indicated that GDIs sustain the activation of Rho GTPase by interacting with GAPs.