Sentence examples for sustaining stemness and from inspiring English sources

During the course of this work, two groups have reported the crucial role of escargot/Snail2 in sustaining stemness and undifferentiated state of Drosophila ISCs in the midgut (Korzelius et al, 2014; Loza-Coll et al, 2014).

Consistent with their role in sustaining stemness of embryonic stem cells, pluripotency-related factors have been suggested to be expressed with higher frequency in tumors displaying lower degrees of differentiation [ 1].

Taken together, the aforementioned data demonstrate that ERK5 signaling inhibition suppresses malignant stem-like phenotypes and function, and support the notion that MEK5/ERK5 is required for sustained stemness in colon cancer cells.

However, according to our experimental conditions, we suggest that IL-8 expression by tumor cells might also contribute to sustained stemness through autocrine signaling.

Fig. 3: PHGDH is required to maintain stemness and self-renewal in CSLCs.

Interestingly, metformin may selectively kill cancer stem cells, since increased dependency on Warburg-like aerobic glycolysis (hyperglycolytic phenotype) is critical to sustain CSCs stemness and immortality.

In this unphysiological surrounding stimulating extracellular matrix and biochemical signals are missing sustaining normally stemness, proliferation, differentiation and development.

Therefore, we wondered if miR-200c had some effects on sustaining the "stemness" of BCSCs.

Our knowledge regarding the molecular basis sustaining somatic stemness features is still very limited but may have important implications for regenerative medicine and cancer therapy.

Genomic profiling studies revealed that Oct3/4 regulates the transcription of a large number of its downstream target genes, either positively or negatively, to sustain the stemness of ES cells [ 70, 71].

Extracellular matrix (ECM) microenvironment is critical for the viability, stemness, and differentiation of stem cells.