Previously, we demonstrated that chronic exposure to Wy-14,643, a non-genotoxic hepatocarcinogen and a potent peroxisome proliferator, results in a rapid and sustained proliferation of PBP/MED1fl/fl hepatocytes that escaped Cre-mediated gene deletion in PBP/MED1ΔLiv mouse livers (27, 32).
Essential thrombocythemia (ET) is one of several myeloproliferative neoplasms in which sustained proliferation of megakaryocytes leads to an excess of circulating thrombocytes (platelets).
The sustained proliferation of this crime in such a hostile legal environment raises an unsettling question: Is slavery inevitable?
Indeed, Fgf8 transcription may not be required to sustain proliferation of axial progenitor cells at late stages of somitogenesis.
However, by week 3, sustained proliferation of CD4+CD25+ and CD4+CD25high, but not CD4+CD25neg T cells, occurred, leading to significant expansion of the CD25+ subsets (Figure 2B).
One of the best studied developmental functions of Tbx1 is in heart development, where it is required to sustain proliferation of mesodermally-derived cardiac progenitors of the second heart field (SHF), a cardiac progenitor cell population that contributes to the development of most of the heart, including the outflow tract and right ventricle [7], [14].
Nicotine sustained proliferation of HC-3-treated cells.
Similarly, E6 prompts the degradation of the pro-apoptotic c-myc protein, resulting in sustained proliferation of infected cells [ 57].
The sustained proliferation of hormone receptor-positive cells during puberty contrasts with results in the adult mammary gland [ 36].
TAMs express an activated phenotype, termed M2, which sustains proliferation of cancer cells, and has been correlated with poor clinical outcomes in human cancer patients.
