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Thus, increasing particle size, and sustaining presentation by DCs and their cognate interactions with T cells underpins the success of the larger particle in driving Tfh differentiation.
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Biomaterials capable of providing localized and sustained presentation of bioactive proteins are critical for effective therapeutic growth factor delivery.
However, most previous studies on this were limited to using high spatial frequencies, sustained presentation, and criterion-dependent methods for assessing threshold.
This effect is largely owing to the collagen-binding domain that serves to sustain presentation of EGF toward cells within the hydrogel.
Experiment 3 explored whether similar local biases occur during sustained presentation of a continually moving target.
Early works on rivalry dynamics (for a review, see [14]) usually focus on the alternating perception during sustained presentation of rivalry stimuli (Figure 1A).
Very recently, the ability of the C-glycoside to stimulate a Th1-polarized response following iNKT cell activation has been attributed to its more sustained presentation compared to KRN7000, despite the finding that iNKT cell TCRs showed a much lower binding avidity to complexes of C-glycoside bound to mCD1d [27].
10.7554/eLife.06994.007 Figure 4. 200 nm particulate antigen challenge promotes sustained presentation of peptide/MHCII by dendritic cells (DCs).
PD-L1hi Cdendriticiticellsls (DC) were uniquely capable of providing sustained presentation of peptide-MHC (pMHC) complexes following PIT.
The sustained presentation observed by DCs was not evident in the B cell compartment, with no significant differences in B cell presentation being detected beyond 24 hr.
Antigen availability can dictate the magnitude of a Tfh response, with sustained presentation by B cells maintaining the Tfh phenotype (Baumjohann et al., 2013).
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