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In this context, excessive autophagy, induced in response to stress signals, can have dual effects, acting either to maintain cell survival (for example, by providing essential energy for sustaining physiological function during the times of catabolic defects) or contributing to cell death (e.g., by diminishing cell volume or providing energy for the execution of apoptosis).
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Not surprisingly, sustained physiological hyperinsulinaemia activates multiple genes involved in inflammation [ 27].
Nevertheless, sustained physiological hyperinsulinaemia activates multiple genes involved in inflammation [ 14].
This sustained physiological response in time causes simultaneous destruction and healing of the injured tissue [ 1].
Metabolic suppression entails reducing the mitochondrial rate while maintaining a core temperature high enough to permit survival and supplying enough ATP to sustain core physiological functions.
Midbrain dopaminergic (DA) neurons sustain important physiological functions such as control of motricity and signaling of positive error in reward prediction in the mesolimbic system (Schultz, 2007).
The diminished amount of CFTR gene product generated by the splicing defect in intron 8 no longer sustains the physiological functions required.
Most organisms experience circadian oscillations of some kind and human biology sustains numerous circadian oscillations that support complex physiological functions.
Since transiently increased gastrin levels have important physiological functions in the gastrointestine, while sustained high gastrin levels (hypergastrinemia) are related to pathophysiological processes [ 7, 8, 10, 14], it is of interest to examine how the duration of gastrin treatment affects gene expression and molecular responses.
The brain is an intricate and complex network of hardwired neurons and glia that sustain a tremendously complex architectural integrity and central physiological function throughout the life of vertebrates.
WILLIAM FREY: This is the only physiological function that humans have that other animals don't have.
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