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We demonstrate that CSC self-renewal, chemoresistance, tumor growth and metastasis formation in vivo relies on the prolyl-isomerase Pin1 functions, sustaining levels and transcriptional activities of two key cell fate determinants, Notch1 and Notch4, strongly implicated in development and progression of breast tumors.
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YouTube this year downgraded its sponsorship of the festival, moving from a "leadership" level to a "sustaining" level.
Almost invariably, that sustaining level of post-recruitment PEEP is higher than the initial value.
Displacement in north-east Nigeria, where 1.4 million people have been forced to flee Boko Haram, may contribute to sustained levels of migration towards Europe in the future.
This model means that across our output we are able to sustain levels of investment in programmes that are central to delivering our remit".
Maintaining sustained levels of angiogenesis inhibitors is crucial for prolonged suppression of angiogenesis.
An IV infusion is a practical approach to introduce sustained levels of compound over a matter of hours, or longer, with the aid of an implanted pump.
Incorporation of αCD into CS (or HA)/PF68 gels resulted on higher rAAV concentrations and sustained levels of transgene expression over time.
Both changes were prevented by subchronic application of bimoclomol suggesting that preservation of endothelial function might be related to sustained levels of HSP-72.
This physiological "wear and tear" resulting from sustained levels of stress or strain has been previously operationalized as allostatic load (AL), a comprehensive indicator of stress exposure.
Everyday hassles and moderate stressors are likely not enough, but sustained levels of worry or stress at a significant level are.
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CEO of Professional Science Editing for Scientists @ prosciediting.com