Exact(3)
SAG-ubiquitination of pro-apoptotic factors strategically supports macrophage survival, sustaining immune defense during early infection.
While declining T-cell immunity has a central role in immunosenescence, DCs remain the major partners for T cells and are equally important in initiating and sustaining immune responses.
Thus, the model of CD4+CD28- NK T cells initiating and sustaining immune responses, and providing a link between the adaptive and the innate immune systems, may hold true for AS disease.
Similar(57)
However, our findings may suggest that higher doses of RES are needed to sustain immune responses; thus, additional experiments are required to fully determine whether RES can maintain immunity during aging.
Protection against diseases is mediated by a sustained immune response.
We show that KLKL5KLK induces a sustained immune response with a prevalent TH2 profile when co-injected with proteinaceous and peptide-based antigens.
For a vaccine to be successful, antigen-presenting cells (APC) need to be stimulated, primarily by adjuvants, towards a sustained immune response through integration of the innate and adaptive (humoral and cellular) immune systems.
HIV infection leads to sustained immune activation and to major alterations in T cell homeostasis [9] [13].
And third, the host must have a defect in immune regulation that allows induction of sustained immune responses against these antigens.
The induction of ASC in the lungs, which are the site of virus entry and replication, is important to maintain sustained immune responses after vaccination.
Further, this elevated cytokine milieu could favor continued or sustained immune cell activation, resulting in continued cell turnover, and destruction of viral target cells in SIV infection.
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