In fact, weather-related power interruptions often tend to be of high impact and sustained duration, ranging from hours to days, because of the large damage on transmission and distribution facilities.
In contrast, the TLR2 agonist, Pam3cys, and the Th2 stimulus, schistosome egg Ags: 1) barely induce IL-12p70; 2) stimulate sustained duration and magnitude of extracellular signal-regulated kinase 1/2 phosphorylation, which results in stabilization of the transcription factor c-Fos, a suppressor of IL-12; and 3) yield a Th2 bias.
This learning criterion has an intuitive interpretation as earliest timepoint at which we can be reasonably certain that the subject is capable of performing the task at consistently above-chance level for a sustained duration.
C1A was designed to have sustained duration of HDAC inhibitory activity via an aromatic nitrogen mustard moiety.
The ideal anticonvulsant should be easy to administer, provide a rapid and sustained duration of anticonvulsant action, and be safe [ 7].
Painful symptoms of diabetic peripheral neuropathy are thought to be triggered by increased depositions of sorbitol, fructose, advanced glycation end products, and free oxygen radicals which reflect uncontrolled hyperglycemia and its sustained duration.
MK-3475, also known as pembrolizumab, received accelerated FDA approval for treatment of advanced melanoma based on high response rates and sustained duration of response in early studies in this disease.
Improvements in the adjusted mean changes from baseline for UMEC QD doses in 12 24-hour 12 24-hourean FEV1 over placebo weightederally simeanr or greater than those observed FEV10–12-hoverweighted mean FEV1, indicating sustained duration of action (Table 5).
Brimonidine tartrate offers clinicians the first topically effective agent for the treatment of facial erythema of rosacea, providing a rapid-onset effect, sustained duration, and good tolerability from both clinical trials and real-world experiences.
Male T. oceanicus produce a complex courtship song consisting of two elements, the short chirp followed by a prolonged trill, and females are known to prefer courtship songs with an overall higher duty cycle and sustained duration of trill [ 46].
We found that cold effects were mostly attributable to extreme low temperatures rather than any added effect related to sustained duration of the low temperatures, which is similar to Huang et al.'s finding that added effects may contribute small proportions in the total effects of cold spells on CVD mortality in Brisbane [ 30].
