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Its communicative status is at a sufficient level of ambiguity that natural mechanisms for sustaining cells are licensed as part of its repertoire.
In summary, telomerase is critical for the maintenance of telomeres in pediatric ependymoma and for sustaining cells with limitless proliferation that may contribute to recurrence.
Ultimately, there is a need to directly address the relevance of normal cancer cells to cancer initiating cells and cancer sustaining cells.
It is unclear whether this survival advantage is due to an intrinsic biological element of the tumour cells which enables successful surgery and improved prognosis, or alternatively the number of tumour sustaining cells remaining irrespective of differences in biology.
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Membrane microdomains also appear to contribute to shaping and sustaining cell polarity.
Alterations on glucose consumption and biosynthetic activity of amino acids, lipids and nucleotides are metabolic changes for sustaining cell proliferation in cancer cells.
Indeed, in absence of Scd1, the SFA content increases which alleviates Akt activation normally obtained by MUFA (e.g. oleic acid) for sustaining cell proliferation and survival [29].
The mammalian pacemaker in the suprachiasmatic nucleus (SCN) contains a population of neural oscillators capable of sustaining cell-autonomous rhythms in gene expression and electrical firing.
Transporters may affect photosynthetic rate via metabolite transport, hormone signaling and sustaining cell homeostasis.
The key role of glucose and glutamine in sustaining cell growth, proliferation and effector function of T cells is undebated.
Much evidence supports their importance in causing and sustaining cell transformation in model systems and in human cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com