Sentence examples for sustaining activation of from inspiring English sources

Hypoxic preconditioning as well as A2aR stimulation induces, in fact, a RhoA-GTPase-dependent inhibition of the diacylglycerol kinases θ, thus increasing diacylglycerol (DAG) and sustaining activation of the DAG-dependent PKC δ and ε [ 28].

This agent induces sustained activation of mitogen-activated protein kinases (MAPK), including JNK and p38 MAP kinases.

These data suggest that the sustained activation of ERK activity be associated with the development of antinociceptive tolerance to morphine in mice.

56, 57 Increased sPLA2-IIA levels could possibly contribute to the sustained activation of mitogen-activated protein (MAP) kinase, resulting in delayed terminal differentiation and hyperproliferation of keratinocytes.

Thus, NS-associated SHP2 mutants display increased phosphatase activity and promote sustained activation of the RAS-ERK1/2 pathway.

Furthermore, we uncovered that increased Bim expression required sustained activation of signal transducer and activator of transcription 1 (Sthroughhrough increased production of inflammatory cytokines.

Increased Bim expression in retinal PCs under high glucose conditions required the sustained activation of signal transducer and activator of transcription 1 (Sthroughhrough production of inflammatory cytokines.

A single oral administration of dh404 was found to dramatically enhance Nrf2 activity, leading to a sustained activation of the cardioprotective genes that are driven by Nrf2 [24].

This modification results in loss of its lipid phosphatase activity and yields a more sustained activation of signaling events downstream of PI3K.

25 Additionally, GSH depletion led to sustained activation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), which inhibits myogenesis.

The activated astrocytes release cytokines, prosanoids, and NO to the subarachnoid space and produce sustained activation of trigeminal nerve fibers.