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"Although the risks of sustaining a chronic musculoskeletal disorder from using a computer are relatively low, some people do experience short-term aches and pains," says a spokesperson for the Health and Safety Executive.
Thus the chemokine CxCL-13 might play a critical role in organizing immune responses within CNS by providing favorable microenvironmental preconditions for compartmentalizing B cell response and sustaining a chronic inflammatory process in the CNS.
Consequently, the ability of tau to activate classical complement pathway could provide a mechanism for initiating and sustaining a chronic, low-level cerebral inflammatory response that may cumulate over the disease course and contribute to PTSD after blast injury.
Beyond the specific challenges of sustaining a chronic disease research partnership, we identified and discussed the importance of social capital, measurable goals, administrative support, creative and innovative strategies and funding as five key ingredients that are essential for sustaining research partnerships generally.
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Prior to Christmas 2001, Bostaph sustained a chronic elbow injury which hindered his ability to drum, resulting in his decision to leave the band.
Due to the reduced IL-10 expression in WT-infected gerbils, the Th1/Th2 equilibrium, which sustains a chronic inflammation, is deranged resulting in a hypergastrinemia and atrophy of the parietal cells in the oxyntic mucosa.
HCV evades the host immune system to sustain a chronic infection.
Conversely AKR mice sustain a chronic Trichuris infection, respond with a TH1 immune response (IFNγ, IL12), and subsequent establishment of colitis [ 8].
When the precipitating insult or injury is sustained, a chronic aberrant wound response can ensue and result in progressive disease; as is the case in chronic obstructive pulmonary disease or hepatitis-associated liver fibrosis [ 3, 4].
Still, low levels of Psy in CNS tissues (comparable with those measured in asymptomatic UT Twi mice at PND10) (50) might sustain a chronic inflammatory response and hamper remyelination attempts.
Thus, over time, the anti-myelin T cell repertoire may broaden and diversify, and may acquire sufficient clonotypic diversity to sustain a chronic or progressive autoimmune course independent of any recurring infectious disease trigger.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com