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The purpose of this study was to investigate the effects of the properties of a drug on its release behavior in a cylindrical sustained-release formulation having a two-component structure, with a silicone matrix containing drug powder as the inner layer component, and with its lateral side covered with an silicone outer layer (CR silicone formulation).
To characterize the phenomenon of dissociation of the 2 components of the sustained-release fluocinolone acetonide implant (Retisert; Bausch & Lomb) during removal or exchange procedures, or both, and to evaluate outcomes after these events.
A simple two-component system for sustained-release caffeine formulation therefore has been achieved.
§ 520.2260b Sulfamethazine sustained-release boluses.
§ 520.2260c Sulfamethazine sustained-release tablets.
§ 520.1197 Ivermectin sustained-release bolus.
§ 520.1450c Morantel tartrate sustained-release trilaminate cylinder/sheet.
Sustained-release lutein delivery was achieved using NLC technology.
Only divalproex-ER demonstrated true sustained-release characteristics.
In vitro drug release studies of this formulation suggested a sustained-release profile.
One challenge in tableting of sustained-release multiparticulates is maintaining the desired drug release after compaction.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com