Sentence examples for sustained uncontrolled from inspiring English sources

They constitute attractive pharmacological targets for development of anticancer therapeutics, since they are frequently deregulated in human cancers and contribute to sustained, uncontrolled tumor proliferation.

On the contrary, sustained, uncontrolled activation of brain macrophages and glial cells can lead to excess production of various pathogenic factors that contribute to neuronal injury, including the significant and dramatic upregulation of proinflammatory chemokines, cytokines and ROS.

Correlations between MCP-1 and CD4+ LPL and between MMP-9/TIMP-1 randos and CD8+ LPL further suggest that these parameters are linked to sustained, uncontrolled antigenic stimulation at the gut mucosal interface.

Another oncogenic AS event that sustains uncontrolled proliferation of cancer cells affects the cyclin D1 (CCND1) protooncogene.

The ability to sustain uncontrolled proliferation represents the most fundamental trait of cancer cells. 1 One of the barriers that limit uncontrolled cell proliferation is cellular senescence, which represents a natural tumor suppressor mechanism.

This is necessary for maintenance of tissue homeostasis and host defense, but can cause bystander damage when the activation is sustained and uncontrolled.

It is now well known that radiation exposure of normal tissues generates a sustained and apparently uncontrolled inflammatory process.

Because if you have uncontrolled immigration, you have uncontrolled pressure on public services.

Uncontrolled and sustained inflammation, however, leads to auto-inflammatory syndromes and sometimes to autoimmune diseases.

Uncontrolled and sustained hyperglycemia is the pathological basis of both type-1 and type-2 diabetes.

However, uncontrolled and sustained secretion of inflammatory cytokines by microglia also trigger neuronal cell death [ 4].