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This level of response was sustained through week 24.
Despite sirukumab crossover to placebo at week 12, clinical response was durable and sustained through week 24 (figure 2).
Clinical improvements observed in patients treated with golimumab through week 24 were sustained through week 256 (5 years).
Benefits were sustained through week 12 for a well-educated, mostly female and computer savvy self-selected population.
produced rapid and significant improvements in trough FEV1, compared with placebo, which were apparent on day 1 and sustained through week 26 [ 8].
CZP-treated patients reported significant improvements from baseline in pain VAS and patient's global assessment of disease activity, evident at week 1 and sustained through week 52.
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However in summary the aripiprazole treatment group (n = 268) resulted in significantly better effectiveness than SOC (n = 254; P < 0.001; week 26 LOCF) as evidenced by the IAQ total score beginning at the first assessment point (week 4) and this was sustained through to week 26.
In addition, significant reductions in DLQI and itch-VAS scores were reported at 8 weeks and sustained through 16 weeks in the 25-mg, 75-mg, and 150-mg ixekizumab groups compared to the placebo group.
Significantly more patients in the 25-mg, 75-mg, and 150-mg ixekizumab groups had a sPGA score of 0 (clear of disease) or 1 (minimal disease) than in the placebo group at week 12. Significant differences between the 150-mg group and the placebo group in PASI 75 and sPGA were identified at as early as 2 weeks and sustained through 20 weeks.
Clinical responses were durable and sustained through to week 24.
For infliximab, the very high response rates obtained after 10 weeks of treatment appear to be sustained through 24 weeks but show a moderate reduction through 48 weeks with infusions every 8 weeks.
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CEO of Professional Science Editing for Scientists @ prosciediting.com