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Strikingly, B6 and C3 clones were overwhelmingly Oct4+, Nanog+ and Stro1+, and sustained the expression of these markers up to the tested 5 passages (Fig. 2B; Fig. 2C E for B6; Fig. 2F H for C3).
Equivalent levels of IFN-α appeared in the BAL fluid of both groups of virus-infected mice at day 2 post-inoculation and declined for the control group at day 3. Interestingly, levels of IFN-α in PT-treated mice on day 3 were significantly higher than in control mice (322 vs. 122 pg/mL, P = 0.0212), suggesting that PT treatment sustained the expression of IFN-α.
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This is in marked contrast to the inability of IL-2-deprived T cells to sustain the expression of endogenous or ectopically expressed retroviral wild-type Myc (Fig 3D).
These data show that in the absence of IL-2, CTL cannot sustain the expression of Myc from endogenous or ectopically expressed retroviral Myc transcripts.
We show that the IKKβ-NF-κB cascade sustains the expression of anti-oxidant genes and that inactivation of this cascade impedes the scavenge capacity and results in ROS accumulation.
EMT process ongoing in embryogenesis is named Type I and Type II is linked to regeneration/fibrosis). OPN is able to bind different integrin receptors and several transcription factors regulated by TGFβ sustain the expression of OPN.
Therefore, menin was dispensable for the initiation of the heat shock response but was required to sustain the expression of heat shock protein genes.
A PcG gene, Rae28, has previously been shown to be required for sustaining the expression of the cardiac selector gene Nkx2.5 in developing mouse embryos [47].
This work thus suggests that during ABA signaling, one physiological role of SnRK2-mediated phosphorylation is to sustain the expression of a subset of ABA-regulated genes by slowing the degradation of specific ABFs.
This indicates that GacSGacA is the sole determinant of the expression of the genes of the hrp regulon and that ectopic expression of other components cannot initiate or sustain the expression of the regulon.
However, the induction of Hsp genes was normal after a 10 min heat shock treatment (Fig. 6B, lanes 1 4), suggesting that menin was not required for the initiation of the stress response but was critical for sustaining the expression of heat shock protein genes.
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