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Notably, sustained stimulation by VEGF-loaded PLLA mat resulted in a substantial increase in the expression of proangiogenic mRNAs of CSCs in vitro.
Cartilage regeneration continues to challenge engineers and a new wave of efforts focus on developing strategies that provide sustained stimulation to cells by growth factors and other biological molecules to promote their differentiation into chondrocytes.
In fact, it has been found that sustained stimulation of TrPs may induce central sensitization in healthy participants [7].
We found that directional selectivity during sustained stimulation with whisker deflection sequences depended strongly on stimulus frequency.
Pindolol led to a DMR similar to that obtained under the sustained stimulation, but with a slower kinetics (Fig. 5b).
Conversely, under the two sustained stimulation conditions (i.e., static and continuous flow) the cells completely lost their responsiveness to the second stimulation (Fig. 4b).
Under the sustained stimulation of interstitial flow, the synthetic SMCs and activated FB and MFB gain higher motility and migrate into the intima or wound sites.
Bilateral electrolytic lesions of the pneumotaxic center weakened the adaptation to PEEP, whereas sustained stimulation of the pneumotaxic center weakened the entrainment independent of PEEP.
Bilateral lesions of the dorsolateral pons weakened the respiratory adaptation to PEEP whereas sustained stimulation of the dorsolateral pons weakened the entrainment independent of PEEP.
These studies support a role for ARF6 in lipid trafficking and suggest that sustained stimulation of endosomal recycling increases cholesterol efflux out of the cell, thereby decreasing intracellular cholesterol accumulation.
Results showed that salbutamol behaved similarly to epinephrine, both resulting in a separation of the single phase P-DMR under the sustained stimulation into the biphasic P-DMR events (Fig. 5a).
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