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Results revealed several regions, including a region in the right lateral inferior frontal gyrus, that exhibited opposing developmental trajectories in sustained and transient signals in particular, decreased sustained signals and increased transient signals with age.
BEIJING -- An Australian ship towing a U.S. Navy "pinger" locator has twice picked up sustained signals that may be from missing Malaysia Airlines Flight 370's "black boxes," and searchers are likely to deploy an underwater exploratory vehicle soon to look for wreckage, authorities said Monday.
However, the role of CNG channels and Ca2+ stores in generating transient and sustained signals downstream from the cone OS is unclear.
Also, the mutant form of growth factor receptor that cannot associate with a responsible E3 induces sustained signals and promotes hematopoietic malignancy (e.g., leukemia) [7], [8].
Therefore, RhoGDIs and GAPs might participate in the switching between transient and sustained signals of the Rho GTPases.
RhoGDIs positively regulate Rho GTPase signaling primarily by interacting with GAPs and may participate in the switching between transient and sustained signals of the Rho GTPases.
Similar(46)
Another feature of the induction of the extension process is its requirement for sustained stimulation, suggesting the need for sustained signaling activities, such as ERK, PI3K or other molecules.
Alternatively, the reduced proteolysis rate in a disturbed endolysosomal pathway might increase the time of transit of receptors in signaling-competent endosomes, leading to sustained signaling.
Sustained signaling requires constant supply of antigen-binding T cell receptors to the immunological synapse.
However, it has been demonstrated that some GPCRs activate G proteins from within internalized cellular compartments, resulting in sustained signaling.
TCR internalization was also required for sustained signaling and activation of key metabolic pathways, including the mechanistic target of rapamycin (mTOR) (Willinger et al., 2015).
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