Other clinical studies have shown improvements in glucose-induced insulin secretion, β-cell sensitivity, and suppression of 24-hour glucagon secretion following 1 week of therapy, 37 and sustained β-cell sensitivity to glucose over 12 weeks of therapy.
UACC-812 TR showed no response to F (P = 0.7004, TR + T versus TR + T + F for UACC-812 TR), and BT474 TR sustained the same modest sensitivity to F as parental cells.
More recently, electrophysiological studies using green fluorescent protein identified GnRH neurons in mice have shown exquisite sensitivity to kisspeptin with sustained action potential firing [38], [39].
Little is known relative to a differential regulation of this mechanism to sustain differences of tissue sensitivity to auxin [35] and our data suggest that ABP1 is involved in this process.
Apoptosis (programmed cell death) has been proposed to play a role not only in cancer onset and progression but also in sustaining decreased tumour cell sensitivity to chemotherapy (Hickman, 1992; Thompson, 1995), which still represents one of the main prognostic indicators in this neoplasia (Hoskins et al, 2000).
As a compromise between Shewhart and sequential approaches, such as CUSUM, we can modify the Shewhart approach by including runs rules which increases the sensitivity to small sustained changes.
Under these experimental conditions, adaptation shifts the relationship between the channel open probability (P0) and the bundle displacement (X) in the direction of the applied stimulus, canceling the effects due to sustained stimuli while maintaining the sensitivity to transient stimuli [ 43].
However, in the presence of millimolar t-tubule Mg2+, the differential sensitivity to caffeine was sustained.
In truth we have no cogent explanation why, as in other observations [ 1, 8] there is sustained damping down of cough reflex sensitivity to citric acid with the Mefar technique and why this is not seen with the KoKo DigiDoser.
