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This sustained replication causes a major viremia, and leads to the development of minor influenza-like symptoms.
Nevertheless, O. anthropi was not able to achieve sustained replication, even though some survival was observed (Fig. 1B).
This permits sustained replication of cytolytic FMDV over several passages in the presence of elevated concentrations of R, thus allowing evaluation of the effects of genetic and environmental conditions on the kinetics of extinction.
Following one passage in PTMs, HIV-2 F escaped host control and sustained replication, showing that the virus adapted to the new host via serial passage.
The low level sustained replication of HCMV in macrophages could favor the formation of reservoirs of virions, and the use of HDACi could reactivate the virus which could be targeted with antiviral compounds such as ganciclovir.
Particularly, efficient and sustained replication of EBV particles in primary human monocytes has been confirmed and shown to alter a number of cellular defense mechanisms.
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Minigenome replicon studies showed that Henipavirus N, P and L proteins are necessary and sufficient to sustain replication of viral RNA [11].
TPH1-dependent serotonin production sustains replication of hepatocytes in the regenerating liver [ 14] and regulates bone mass [ 13].
We found that mutations in THO and TREX-2 genes counteract HU sensitivity and fork reversal in checkpoint mutants, thus sustaining replication fork progression.
The sustained viral replication causes secondary viremia and leads to the development of minor symptoms such as fever, headache and sore throat.
Following reactivation of latent virus, impaired cellular immunity enables sustained viral replication to occur in urothelial cells, which potentially leads to the development of BKV-associated nephropathy (BKVAN).
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