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Reductions in Sost transcript in response to PGE2 were rapid, occurring within 1 hr of PGE2 addition, and were sustained, remaining at 30% expression compared to vehicle-treated samples after 24 hours of culture.
Compared to K9ac, these increases are slower and more sustained, remaining after 2 h of stimulation.
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The mechanisms by which the ES cell cycle is controlled and sustained remain obscure.
The responses then declined, but remained above baseline for several hundred ms. This sustained component remained linearly dependent on morph level for stimuli more similar to the ineffective image but progressively converged to a single response profile, independent of morph level, for stimuli more similar to the effective image.
Still, economic stability, let alone sustained recovery, remained well out of sight.
Maximum sustained winds remain near 85 miles per hour with higher gusts.
In Virginia, Tropical Storm Danielle produced peak wind gusts of 61 mph (98 km/h) at Cape Henry, though sustained winds remained below tropical storm strength.
As the trapped monomer demonstrates, if WT CXCL8 did not dimerize, its recruitment though sustained would remain low.
However the stem loops, which have also sustained mutations, remain thermodynamically stable (delta G of −15.8 kcal/mol vs −14.0 kcal/mol) and the motif is unchanged.
Moreover, the relationship between time-to-remission and sustained remission remained significant.
Despite the clinical value of computerized health problem lists, their adoption and sustained utilization remain low [ 15- 17].
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