Sentence examples for sustained progression from inspiring English sources

The most essential requirement for a valid MRI outcome measure is that its findings are predictive of future clinical outcome, especially sustained progression in disability.

The author found, between 15.8 and 42.2 % of patients experienced sustained progression based on the definitions using EDSS as the outcome, but nearly 50%% of these patients failed to maintain sustained progression for the duration of follow-up.

The risk of 24-week sustained progression of disability was also reduced significantly among patients receiving DMF BID (29%) and TID (32%) compared with patients in the placebo group.

The risk of 12-week sustained progression of disability over 2 years was reduced significantly among patients receiving DMF BID (32%) and TID (30%) compared with patients in the placebo group.

In the AFFIRM study, 23 Tysabri® (NA); administered to 627 patients with RRMS at a dose of 300 mg every four weeks for more than two years, produced a reduction of sustained progression of disability by 42%.

More recent findings [ 21] suggest that even a consistent effect of on-study relapses on subsequent "sustained progression" could not be interpreted as evidence for a link between relapse frequency and the accumulation of true, unremitting disability.

Reduced-intensity-conditioning allotransplantation produces sustained progression-free survival and overall survival (40%-60 40%-60years), equivalent to the cure of the disease, even in cases with adverse biomarkers.

Recent advances that incorporate combination chemotherapy and the anti-CD20-targeted agent rituximab (Rituxan) have improved the clinical outcome of patients diagnosed with diffuse large B-cell lymphoma (DLBCL), but only 60% of all DLBCL patients are potentially cured and achieve sustained progression-free survival (PFS).

These species damage DNA, producing the mutations that initiate tumours and sustain progression [ 1].

As a result of these conditions (more details are given in Figure 13), persistent inflammatory reaction and chronic activation of the wound healing response will occur, sustaining progression of fibrogenesis to the end-point of cirrhosis [ 74- 83].

In general, patients with ≥1 relapse per year, absence of complete recovery from relapses, sustained disability progression of ≥1 and MRI progression, with or without clinical signs, are considered as 'treatment non-responders', justifying the transition from basic to escalation therapy [9].