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This action leads to sustained membrane damage and, eventually, cell lysis.
In contrast, the sustained membrane depolarization and inward current in response to LPI were not affected by the GPR55 blocker.
Acquiring IDH1 mutations comes at a price however, as it will pose the cell with an excessive need for exogenous sources of α-KG for sustained membrane synthesis.
Bisphenol A also induced sustained membrane stress at 15 min, which might be contributed by one of the intermediates identified, 1,4-benzoquinone.
The subsequent inhibition of the non-selective cation channels by 100 µM La3+ in the presence of ouabain completely prevented LPI-induced, sustained membrane depolarization.
The slow inactivation state of neurones is induced under conditions of repetitive neuronal firing and/or under conditions of slight or sustained membrane depolarisation.
Similar(40)
A titration experiment revealed that a minimum concentration of 0.1 mM of a salt such as KH2PO4 is required to sustain membrane permeability.
The problem seems to be that the cells with only one copy of the XOR gene could not replenish their supply of the protein fast enough to sustain membrane production.
Our data also indicated a differential requirement of the molecular interactions of Ocrl1 for sustaining membrane remodeling vs. PC assembly.
In the procedure, the obstructed tissue was cauterised to an eschar crust tube tightly adhering to the wall of the reopened cavity, and became a transitorily sustaining membrane to the wall of the reconstructed nasolacrimal duct.
Deoxygenation-induced elevation of [Ca2+]i might require or be sustained by membrane hyperpolarization caused by KCa3.1 activation.
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