Nanosphere delivery of therapeutic molecules is attractive for treatment of SCI for many reasons: they are minimally invasive and provide sustained local drug release, which results in a higher dose locally without systemic side effects.
This delivery formulation may be clinically useful for sustained, local protein drug delivery applications.
In this study we present a surface modification method designed for sustained local release of Sr from implants.
Mr. Levy said that FEMA's response to Katrina was inadequate and that it demonstrated the importance of a sustained local disaster-management response.
Without sustained local and international pressure to overhaul the autocratic political leaderships that dominate the Arab world and to hold democratic elections, only cosmetic change can be expected.
Hydrogels are high-water content materials prepared from cross-linked polymers that are able to provide sustained, local delivery of a variety of therapeutic agents.
Although anti-inflammatories show poor performance in clinical trials, their efficacy treating IVD cells suggests that sustained, local drug delivery directly to painful IVDs may be beneficial.
Sustained, local, low dose growth factor stimulus of target tissues/cells is believed to be of imminent importance in tissue regeneration and engineering.
Neurotrophin-3 (NT-3) has shown promise in regenerative strategies after spinal cord injury; however, sustained local delivery is difficult to achieve by conventional methods.
We conclude that the sustained local IGF-1 availability from fibrin provided by our variant protein enhances smooth muscle regeneration better than the WT form of the protein.
It launches in uncertain territory: the UK has yet to produce a successfully sustained local TV channel, with Manchester's Guardian-owned Channel M perhaps the most promising endeavour before it gave in to market pressures last year.
