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For vaccines, having a desirable stability could ensure prolonged circulation in blood and sustained induction of immune response.
In other models sustained induction of Myc leads to tumor development [43].
However, there was sustained induction of IL-10-producing and FOXP3 positive antigen-specific T cells.
Previously a sustained induction of Fgf2 mRNA levels in spite of insulin treatment at a one month time point has been reported [55].
Acting as a cytokine, it is a potent regulator of AsNOS expression with low doses resulting in sustained induction of anti-parasitic AsNOS [41].
We find that DosT and DevS mediate a rapid and sustained induction of the DevR regulon, respectively, in response to hypoxia achieved through the O2-scavenging and reducing property of AA.
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Significant up-regulation at 3 h post inoculation and sustained induction was observed for another set of miRNAs (e.g. miR159, miR393).
These data confirm similar results to those obtained in vitro and suggest, on the basis of rapid and sustained induction, that peIF2α increases represent the most attractive candidate for an OXY response biomarker.
As shown in Figure 4C, a modest induction of RARβ mRNA was seen in HepG2 cells 6 hours after fenretinide treatment, but no sustained induction at 48 hours.
The expression profile of Fkbp5 exhibits an initial delay, followed by a robust and sustained induction.
Therefore, hypoxia-responsive transcription factor(s) are likely to sustain the induction of iNOS by LPS (shown here) or by IL-1 β and interferon- γ (Van den Berge et al, 2001).
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