IRs rated as severe in the OLE occurred in four patients, none of whom sustained goal range urate lowering, and in seven patients who received placebo in the RCT.
In the present OLE of two RCTs, 17 long-term treatment with pegloticase was safe and generally well tolerated, especially in patients who had experienced sustained goal range urate-lowering responses during blinded treatment.
Given that participants are usually free to relax their attention and "mind wander" for the remainder of a trial once they have responded to the stimulus, neural activity in frontal regions necessary for sustaining goal-directed attention should persist for the duration over which attention is maintained [cf. 43], [44] a duration closely indexed by RT.
Another explanation is that in deprived individuals the brain systems that control behaviour are weaker, leading to a reduced ability to sustain goal-directed behaviour, such as quitting smoking, and in particular an inability to inhibit responses that may be cued by cravings or exposure to others smoking [ 28].
For example, in the cohort of patients sustaining goal urate-lowering on the biweekly pegloticase OLE dose schedule, flares diminished substantially (occurring in 26% (9/35) during months 1 3 of the OLE study, 9% (3/32) during months 10 12 and 3% (1/29) during months 22 24).
Provided the recovery is sustained, our goal is to achieve that surplus in the next Parliament.
Many in the Ethiopian government, ruling party and security apparatus acknowledge that only further reforms can sustain the goals of economic growth and political stability.
In the years leading up to the wars in Afghanistan and Iraq, thinking about defense was driven by ideas that regarded successful military operations as ends in themselves, rather than just one instrument of power that must be coordinated with others to achieve, and sustain, political goals.
Publishing findings in scientific literature is critical to sustaining the goals defined under our MEPI programme.
While major achievements have been realised, she noted the need to address salient issues to realise and sustain the goals.
