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IRs rated as severe in the OLE occurred in four patients, none of whom sustained goal range urate lowering, and in seven patients who received placebo in the RCT.
In the present OLE of two RCTs, 17 long-term treatment with pegloticase was safe and generally well tolerated, especially in patients who had experienced sustained goal range urate-lowering responses during blinded treatment.
"So increasing engagement, mobilization, and representation of people of color must remain an important and sustained goal of Democrats".
But without a sustained goal, One Love can funnel money to whatever cause it sees fit at the moment.
Improving vaccination efficacy represents a sustained goal to improve the control of whooping cough (3, 4) and thereby reducing associated mortality, morbidity and economic costs (5, 6).
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For example, in the cohort of patients sustaining goal urate-lowering on the biweekly pegloticase OLE dose schedule, flares diminished substantially (occurring in 26% (9/35) during months 1 3 of the OLE study, 9% (3/32) during months 10 12 and 3% (1/29) during months 22 24).
Given that participants are usually free to relax their attention and "mind wander" for the remainder of a trial once they have responded to the stimulus, neural activity in frontal regions necessary for sustaining goal-directed attention should persist for the duration over which attention is maintained [cf. 43], [44] a duration closely indexed by RT.
Another explanation is that in deprived individuals the brain systems that control behaviour are weaker, leading to a reduced ability to sustain goal-directed behaviour, such as quitting smoking, and in particular an inability to inhibit responses that may be cued by cravings or exposure to others smoking [ 28].
Provided the recovery is sustained, our goal is to achieve that surplus in the next Parliament.
Without the pressure of playing at home, as the Americans did in the 1996 Olympics and in the 1999 World Cup, perhaps she will be able to sustain her goal production throughout the tournament.
In modeling human cognition as a form of problem solving (goal-directed search and operator sequencing), cognitive science researchers have not adequately studied 'off-task' activities (e.g. waiting), non-intellectual motives (e.g. hunger), sustaining a goal state (e.g. playful interaction), and coupled perceptual motor dynamics (e.g. following someone).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com