Sentence examples for sustained gene expression from inspiring English sources

Recombinant retroviruses provide highly efficient gene delivery and the potential for sustained gene expression, but suffer from significant disadvantages including low titer, expensive production, poor stability and limited flexibility for modification of tropism.

We have recently reported the design of hybrid delivery vectors combining retrovirus-like particles with synthetic polymers or lipids that are efficient, provide sustained gene expression and are more stable compared to native retroviruses.

This leads to a rapid and sustained gene expression, thus, physical delivery systems represent a convenient and efficacious method for gene delivery in vivo.

All these findings indicate that autologous cell gene delivery can make sustained gene expression in the injected area locally.

Numerous cellular/viral promoters that ensure sustained gene expression in various cell types have been identified but systematic comparison of their activities in hESCs is still lacking.

These results showed the feasibility of inducing a sustained gene expression in bones following injections of an HVJ-envelope-DNA complex vector into the muscle.

Here, we test the ability of these vectors to sustain gene expression and phenotypic improvement for the life of the animal.

This situation suggests that, unlike other HP1 isoforms, HP1γ may sustain gene expression in ESC.

In conclusion, the PD1 barrier element, like other functionally defined barrier elements, serves to sustain gene expression and to maintain histone modifications and low nucleosomal density associated with active transcription [30] [32], [38], [44], [48], [50] [63].

Our current data show that an optimal combination of cis-acting elements and promoters/enhancers for sustaining gene expression in chicken cells is suggested.

This demonstrates that bZIP1 is directly or indirectly involved in sustaining gene expression modulation by light, as confirmed by previous studies [ 12].