Exact(23)
Therapeutic efficacy, however, has been limited by diffusion or inactivation of these growth factors from the desired site and by the inability to deliver sustained concentrations of growth factors.
The use of gene transfer methods circumvents problems related to large-scale production and purification and offers additional benefits by achieving sustained concentrations of therapeutic protein with a syngenic glycosylation pattern that make the protein potentially less immunogenic.
Selenoproteins may reach repletion at a plasma selenium concentration of ~ 125 µg/L, at which point the concentration of selenoprotein P reaches a plateau; whether sustained concentrations higher than this are beneficial, or indeed detrimental, is unknown.
Encapsulated cells showed sustained viability during long-term in vitro culture with those encapsulated in multilayer capsules secreting significantly higher and sustained concentrations of 17 β-estradiol (E2) than the two other encapsulation schemes (p < 0.05, n = 6) in response to follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
The toxic gas becomes fatal with sustained concentrations above 150 parts per million, however symptoms of carbon monoxide poisoning, including headache, nausea and dizziness, may present themselves at 70 ppm.
As a 2012 study on MDMA and "interindividual differences due to polymorphisms and drug drug interactions" explained, prior research "suggested that CYP2D6 [poor metabolizers] are more susceptible to the acute effects of MDMA (Tucker et al., 1994), since a deficiency in this enzyme could substantially impair elimination of MDMA, leading to higher and sustained concentrations of MDMA in the body.
Similar(37)
Wanting it more didn't refer to "desire," but to sustained concentration.
As I have discovered, chronic sleep deprivation makes sustained concentration a daunting task.
It's not psychosis; it's sustained concentration.
Top-level games require several hours of sustained concentration.
The partial manuscript — which Little, Brown plans to publish next year — expands on the virtues of mindfulness and sustained concentration.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com