Sentence examples for sustained cell cycle from inspiring English sources

While no anti-proliferative effects were noted in KI/KI h-Ras lines, +/+ h-Ras lines underwent sustained cell cycle arrest.

However, in contrast to the subsequent potent induction of apoptosis in NCI-H929 cells, PBOX-15-treated U266 cells were found to undergo sustained cell cycle arrest.

In theory, sustained cell cycle arrest at G0/G1 phase is coupled with cell differentiation, the stage at which the cell reaches its maximum level of biogenesis and protein expression (Li and Vaessin, 2000; Myster and Duronio, 2000; Steinman et al., 1994; Tang et al., 1999).

Sustained cell cycle arrest leads to cell death.

In turn, p53 maintains a sustained cell cycle arrest by upregulating the expression of the cyclin-dependent kinase inhibitor p21, which arrests the cell cycle at the G1 phase, 12 and 14-3-3σ, whiCDC25Cuesters CDC25C phosphatase in the cytoplasm and promotes G2/M cycle arrest.

Long-term activation of Hog1 leads to a sustained cell-cycle arrest that, when maintained, provokes cells to enter into apoptosis (Vendrell et al. 2011).

At higher doses, cells may experience a sustained cell-cycle arrest, or alternatively cells may breach the cell-cycle arrest and proceed to polyploidy.

Radiation-induced persistently increased ROS and DNA damage could lead to sustained cell-cycle arrest potentially leading to senescence [ 89] and the cell's capability to repair DNA damage including DSB have been reported to decline with advancing age [ 17, 19- 21].

The p53 tumor suppressor protein, through its downstream target p21, plays a key role in sustaining cell-cycle checkpoints after DNA damage to maintain the genomic stability [ 1, 2].

The p53-p21 playsay plays a key role in sustaining cell-cycle checkpoints after DNA damage [ 1, 2], and the expression of the largest exon of FATS is sufficient to activate p53-p21 pandway and suppress tumorigenesis [ 10– 10].

It is expressed at the early stage of G1 phase and is sustained throughout cell cycle.