Griffiths and others have concluded that the idea that genes provide the information while other causal factors merely provide material cannot be sustained under causal theories of information.
Altogether, these findings are clearly consistent with several data sustaining a causal link between DNA hypomethylation and chromosomal instability [ 20– 23].
Although the evidence for a pathogenic nature of the novel mutation p.Trp331dup is not conclusive, segregation in patient LCA45a, her affected aunt LCA45b and her (healthy) parents sustains a causal role.
Bayesian networks represent a 'snapshot' at any given time; however, the networks generated herein reflected sustained effects or causal events seen across multiple time points.
Therefore these functional explanations are sustained by a complex causal feedback loop in which dysfunctional elements tend to be filtered out in competition with better functioning elements.
Further, this commitment to the event-causal framework is sustained by a widespread dissatisfaction with alternative agent-causal and volitionist theories of agency.
On the occasion that the causal agents persist, sustained inflammation is the result, together with connective tissue remodeling, where collagenases, such as matrix metalloproteinase (also transcriptionally driven by pro-inflammatory cytokines) play an active role (Mahé et al 2000).
Nevertheless, static modelling for a time series data is more meaningful under assumption that the effects exist long enough to be visible across multiple time steps and causal events are sustained causes, not one-shot triggers.
While not proving a causal relationship, the sustained, low levels of inflammation described in HIV+ brains even after cART treatment do produce cumulative deficits (Heaton et al. 2010, 2011; Cohen et al. 2010; Gongvatana et al. 2013) and would predict this outcome.
On the other hand, static modelling for a time series data is more meaningful under the assumption that the effects exist long enough to be visible across multiple time steps, such that causal relationships are sustained rather than one-off events.
