Sentence examples for sustained attenuation from inspiring English sources

Therefore, the objective of this study was to advance this technology toward clinical application by investigating the therapeutic potential of IL-1ra-loaded PLGA microspheres for sustained attenuation of IL-1β-mediated NP degradation by using a 3D culture model.

The objective of this study was to investigate the therapeutic potential of poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with interleukin-1 receptor antagonist (IL-1ra) for sustained attenuation of interleukin-1 beta (IL-1β) mediated degradative changes in the nucleus pulposus (NP), using an in vitro model.

Using a genetic mouse model that mirrors partial pharmacological inactivation of p110α, we found that sustained p110α attenuation protects from fat accumulation and deterioration in insulin sensitivity upon ageing and leads to better overall glucose homeostasis compared with control aged mice.

Such issues deserve sustained attention.

It also provides a functional readout for ROR2 signalling although, given ignorance of the downstream signalling pathways employed by ROR2, this could indicate either attenuation or sustained signalling.

We found that reduction of MIF uptake was followed by attenuation of sustained ERK activation after CPZ pretreatment, which suggested the association and consecution between MIF endocytosis and its sustained ERK activation.

The current data suggest that neural specialization between 1 and 4 months may be characterized by selective pruning, given the sustained response to speech coupled with the attenuation of neural responses to other biological non-speech sounds.

After 6 weeks of daily probiotic administration and sustained coronary artery ligation there was a significant attenuation of several indices of heart failure, including cardiac hypertrophy and ventricular remodeling.

Extensive characterization of S-222611 revealed relative insensitivity to attenuation by serum protein binding (Table 1d) and sustained kinase-inhibitory activity (Fig. 2c), both of which contribute to the superiority of S-222611 in the in vivo evaluation.

For our inhibition studies we aimed to achieve so-called "non-toxic proteasome inhibition", i.e. only partial attenuation of chymotrypsin-like activity as high and sustained doses can result in severe toxic effects with detrimental outcomes [ 23].

In this study, we tested the hypothesis that transient attenuation of diet-induced insulin hypersecretion in young mice can provide sustained protection against obesity throughout adult life.