Sentence examples for sustained administration of from inspiring English sources

Furthermore, previous studies in our laboratory, using a mouse monoclonal antibody against NGF (anti-NGF), showed that sustained administration of anti-NGF results in a marked reduction of sprouting and neuroma-like formation by CGRP+, TH+, and NF200+ nerve fibers in the tumor-bearing bone, irrespective of whether the tumor synthesizes NGF [ 35, 46, 71].

Furthermore, despite the latest recommendations on MAP targets of at least 65 mmHg [ 2], even the most recent large clinical trials of septic shock have used higher targets and resulted in still substantially higher actual blood pressure levels during sustained administration of catecholamines [ 8, 9].

In young adults, sustained administration of a D1/D2-like agonist (pergolide) has been shown to impair associative learning (Breitenstein et al. 2006), whilst in another, levodopa (L-dopa) improved new word learning (Knecht et al. 2004), and in a third, bromocriptine improved spatial delayed learning (Mehta et al. 2001); see also (Mehta et al. 2005, 2008; Mehta and Riedel 2006).

The core steps in this treatment are the collection of venous blood, the in vitro incubation of these blood samples with a certain concentration of IL-2, and the subsequent transfusion of the blood back into patients; patients are then treated with sustained administration of an appropriate concentration of IL-2 to maintain LAK activity [ 52, 53].

These traits were recorded either in baseline condition (ctr) or in response to sustained administration of iso at 1 (isor) or 10 (iso10) mg/kg per day or ate at 10 mg/kg per day for two weeks.

Sustained administration of opioids in rodents over one week can not only elicit hyperalgesia but also induce neurochemical CNS changes commonly seen with inflammatory pain [ 52].

Further immunostimulation analysis indicated that mRNA levels of S100 calcium-binding protein A4 (S100A4) and S100 calcium-binding protein A6 (S100A6) in porcine PK-15 cells increased within 48 h and were sustained after administration of lipopolysaccharide (LPS) and Poly (I C) respectively.

Further immunostimulation analysis indicated that the mRNA levels of S100 calcium-binding protein A4 (S100A4) and S100 calcium-binding protein A6 (S100A6) in porcine PK-15 cells increased within 48 h and were sustained after administration of LPS and Poly (I C) respectively.

Among the possible strategies to prevent the drug effects on the HER2 pathway in the corneal epithelium, maintenance of sustained activation by administration of a topical serum ligand seemed was proposed as the best solution.

Furthermore, van Raalte et al. (8) raised the possibility that the acute reduction in insulin secretion is not sustained with longer administration of GCs, although the prednisolone doses used were different in their short-term and medium-term studies.

When caregiver costs were excluded from our analyses, ranibizumab treatment was cost-saving at 10-years under only one set of assumptions: sustained-effectiveness, administration of ranibizumab less frequently for only 2 years, and the ranibizumab cost equal to the bevacizumab price (Table 6).