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Their ability to initiate EMT depends upon their ability to repress E-cadherin transcription and, at least for Snail1, sustain this effect despite continual signals targeting it for degradation at the proteasome [ 54].
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The authors concluded that the vaginal probiotic reduced pH and improved other parameters, and that the adjuvant oral probiotic sustained this effect for 6 months.
The duration of hypochlorhydria due to PPI's is variable and not sustained and this effect is unpredictable unless PPI's are reliably taken every day by the patient.
However, some contradictory data showed that, in some culture conditions, IgG secretion and B-cell proliferation can be induced and B-cell survival sustained, and this effect does not depend on the presence of IFN-γ in the culture [ 30, 31].
Parvovirus B19 infection should be considered as a possible cause of an acute, prolonged drop in hemoglobin (Tchernia et al, 1993), although patients have sustained this infection with no effect.
Illness duration was the only predictor of sustained remission and this effect could be detected only when we defined categories of duration.
Results indicated that although pain led to significantly worse performance on the executive functioning task in the no optimism condition, this sustained deteriorating effect of pain on task performance was abolished in the optimism condition.
This study employed a 2 (optimism/no optimism) × 2 (pain/no pain) between-subjects design to explore whether (1) experimentally induced pain (cold pressor task) deteriorates subsequent executive task performance, and (2) whether an optimism induction can counteract this sustained deteriorating effect of pain on executive task performance.
As shown in Figure 1b, AMD3100 was able to mobilize a similarly large number of cells into the circulation at days 1 and 10, indicating a sustained mobilizing effect of this drug.
This sustained effect of RAP-011 as well as the mechanism responsible for EPO induction are very interesting but not fully understood.
Now the term "sustained effect" describes the formerly "persistent effect" which may lead to some confusion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com