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Even after completion of treatment, a significant proportion of patients sustain disability from nerve damage, requiring continued (self-) care to limit further secondary damage (5).
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In general, patients with ≥1 relapse per year, absence of complete recovery from relapses, sustained disability progression of ≥1 and MRI progression, with or without clinical signs, are considered as 'treatment non-responders', justifying the transition from basic to escalation therapy [9].
This effect was more pronounced for 12-month sustained disability worsening events.
In this study, LAQ significantly reduced the risk of sustained disability progression and the rate of MRI-measured brain volume loss by about one-third.
However, there was no difference in sustained disability progression between the two groups There was no significant change in the mean EDSS score.
We found that rates of 3-month confirmed and 12-month sustained disability worsening events after CIS onset were significantly and substantially reduced by DMT treatment.
Next, we assessed whether kif21b levels in MS also correlated with a shorter time to reach EDSS 6.0, a measure for sustained disability.
Interestingly, we observed a trend that abundant kif5a is also associated with a more rapid development of sustained disability in MS (Additional file 1: Table S6).
Predictors of first 3-month confirmed and 12-month sustained disability worsening were assessed using univariable and multivariable Cox proportional hazards regression.
Both interferon beta-1a formulations have achieved reductions in sustained disability progression in relapsing multiple sclerosis when used during the early phase of the disease.
In this small trial, the PLP10 treatment statistically significantly reduced the ARR and the risk of sustained disability progression without any reported serious adverse events.
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