Exact(3)
Sensory-motor incongruence may also directly produce pain, sustain altered motor control strategies and contribute to fear and catastrophic thoughts.
Other short-term interventions also failed to sustain altered learning habits [ 8].
Despite these important observations, the mechanisms by which early life experiences program longer-term changes in gene expression, and whether the observed epigenetic modifications by themselves are able to sustain altered expression of the associated genes in the absence of ongoing, perhaps unidentified, physiological signals, are still unclear.
Similar(57)
New insights into the nature and biology of ER have revealed several mechanisms sustaining altered ER signaling in endocrine-resistant tumors, including deregulated growth factor receptor signaling that results in ligand-independent ER activation, unbalanced ER co-regulator activity, and genomic alterations involving the ER gene ESR1.
Approximately 60% of genes with sustained altered expression levels have no known function.
The consumption of these substrates as well as the production of fatty acids contributes to the sustained altered metabolic state that tumor cells require for growth and survival.
The broader, long term objectives and principles have not been challenged by key stakeholders and have remained at the core of the process of change, but the strategies developed and deployed to achieve and sustain change have been altered and revised across time, to maintain momentum and deal with emerging challenges and barriers.
However, without published ED data, ED directors and administrators may have difficulty motivating staff to alter their practice or sustain change.
– and even the extraordinary David Bowie was only briefly able to sustain the alter egos who observe the dystopian landscapes of Aladdin Sane and Diamond Dogs.
Therefore, it is critically important, especially when studying a topic with policy relevance such as drinking in groups, to test whether effects found in the laboratory are sustained or altered in the field.
Gene expression patterns are likely to undergo recognizable changes in specific regions of the brain to initiate, sustain, and/or modify the altered biological states that accompany behavioral phenotypes, thereby providing an opportunity to characterize the basis of mental disorders [ 3].
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Justyna Jupowicz-Kozak
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