The first step in this direction is the low-glucose suspend pump that is available in Europe and currently in clinical trials in the U.S.
We conducted an in-home randomized trial to determine whether nocturnal hypoglycemia could be safely reduced by temporarily suspending pump insulin delivery when hypoglycemia was predicted by an algorithm based on continuous glucose monitoring (CGM) glucose levels.
In the meantime, reducing the risk of hypoglycemia by automatically reducing or temporarily suspending pump basal insulin infusion rates based on projected low glucose levels is an area of intense research interest.
A sleeved piston pump located in the aorta and a unique, magnetically suspended centrifugal pump are described in the destination therapy section.
As can be seen from Fig. 3, the HPA predicted a pending hypoglycemic event when glucose concentration was ∼104 mg/dl and suspended the pump for 90 min. This resulted in prevention of the event where, in successive simulation without the use of the algorithm, the glucose dropped to extremely low values.
These settings could vary between day and night and be tuned to meet individual insulin sensitivity, allowing the user to enhance specificity that would prevent false alarms resulting in pump suspension, where during the day a more aggressive tuning can be set that can alert the user to take corrective action prior to the need to suspend the pump.
On one hand, longer prediction time may provide greater ability to prevent hypoglycemia events; on the other hand, it may be impractical to suspend a pump too far from an event that may not happen due to human factors (e.g., a planned meal).
The subjects then received a 0.2 unit/kg bolus of aspart or lispro insulin through the insulin pump, and the pump was suspended.
We demonstrate 400-THz (0.6 3.3 µm) bandwidth infrared supercontinuum generation in a 10 cm-long tapered tellurite suspended core fiber pumped by nJ-level 200-fs pulses from an optical parametric oscillator.
This paper reports on the fluidic and electromechanical performance of the resonant microfan as an in-channel gas pump and suspended airborne particle collector.
The infusion of insulin via the insulin pump was suspended just prior to the administration of aspart and detemir.
