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In 1996, Deleuze et al. [1] initially suspected the role of defects in the multidrug resistance 3 P-glycoprotein (MDR3) in a subtype of progressive familial intrahepatic cholestasis (PFIC).
Furthermore, a study based on MOLT-4 cell lines also suspected the role of alterations in the MMR system in the resistance phenotype to 6-MP [ 54].
Similarly, although strongly suspected, the role of humans and other animals in the dispersal of G. destructans and the effect of such dispersals in bat infections have not been confirmed.
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In particular, the distribution of IgG antibody subclasses has led us to suspect the role of helminthic infections on acquisition of immunity to malaria [2].
The temporal relationship between sibutramine intake and onset of behavioral changes as well as the decrease in manic symptoms with cessation of sibutramine and initiation of anti-manic pharmacotherapy led us to suspect the role of sibutramine in the pathogenesis of manic episode.
Given this association of myasthenia and acute HEV infection, we suspected the potent role of HEV infection in the neurologic symptoms.
Years ago, Canadian researchers performed a small study to confirm what researchers suspected about the role of body size they immersed a small group of women up to their necks in cold water to see how quickly their temperature dropped, and found it did drop in relation to their surface-area-to-volume ratio and body fat.
Environmental factors, including UVL exposure from the sun and tanning sunbeds 4 could be suspected, but the role of some chemical xenobiotics, particularly hormonal disruptors, 11– 13 is not ruled out.
The strong correlation between uveal injury and sympathetic ophthalmia also led some to suspect the pathogenic role of the uvea, citing the presence of antiuveal antibodies in a large percentage of patients with sympathetic ophthalmia.
We suspect the differential roles of cohesin ATPase active sites and a specialized role for the Smc3 active site in DNA tethering was missed previously, in part due to their composite nature and the particular mutations that have been analyzed to date.
Although VEGF's role is suspected, the precise mechanism by which VEGF levels influence osteoarthritis remains largely unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com